Latest HBOT Research
Stay up to date with the latest scientific research and clinical studies on hyperbaric oxygen therapy. Our database is regularly updated with new findings and breakthrough discoveries.
Bhutani S, Vishwanath G (2012). Hyperbaric oxygen and wound healing. Indian J Plast Surg, 45(2), 316-324.
Thom SR (2011). Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg, 127(1), 131S-141S.
DOI: 10.1097/PRS.0b013e3181fbe2bf
Thom SR (2009). Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol, 106(3), 988-995.
DOI: 10.1152/japplphysiol.91004.2008
Wingelaar TT, Brinkman P, van Ooij PJAM, et al (2019). Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis. Front Physiol, 10, 475.
Gill AL, Bell CNA (2004). Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM: An International Journal of Medicine, 97(7), 385-395.
Rossignol DA, Bradstreet JJ, Van Dyke K, et al (2012). Hyperbaric oxygen in autism spectrum disorders. Med Gas Res, 2(1), 16.
Rossignol DA, Rossignol LW, Smith S, et al (2009). Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial. BMC Pediatr, 9, 21.
Xiong T, Chen H, Luo R, et al (2016). Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Cochrane Database Syst Rev, 10(10), CD010922.
DOI: 10.1002/14651858.CD010922.pub2
Rossignol DA, Rossignol LW (2006). Hyperbaric oxygen therapy may improve symptoms in autistic children. Medical Hypotheses, 67(2), 216-228.
DOI: 10.1016/j.mehy.2006.02.009
Rossignol DA, Frye RE (2014). Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol, 5, 150.
Fife CE, Eckert KA, Carter MJ (2016). An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg, 138(3), 107S-116S.
DOI: 10.1097/PRS.0000000000002714Fujita N, Ono M, Tomioka T, et al (2014). Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One, 9(12), e115685.
DOI: 10.1371/journal.pone.0115685Thom SR (2009). Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol, 106(3), 988-995.
DOI: 10.1152/japplphysiol.91004.2008Vadas D, Kalichman L, Hadanny A, et al (2017). Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci, 11, 25.
DOI: 10.3389/fnint.2017.00025Hink J, Jansen E (2001). Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med Hypotheses, 57(6), 764-769.
Harch PG, Fogarty EF (2019). Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Med Gas Res, 8(4), 181-184.
Shapira R, Efrati S, Ashery U (2018). Hyperbaric oxygen therapy as a new approach for Alzheimer’s disease. Neural Regen Res, 13(5), 817-818.
Qiang L, Su-qin X, Yu-fen Y, et al (2019). Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia. Front Aging Neurosci, 11, 86.
Efrati S, Golan H, Bechor Y, et al (2015). Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial. PLoS One, 10(5), e0127012.
DOI: 10.1371/journal.pone.0127012Yildiz S, Kiralp MZ, Akin A, et al (2004). A new treatment modality for fibromyalgia syndrome: hyperbaric oxygen therapy. J Int Med Res, 32(3), 263-267.
DOI: 10.1586/eri.09.76Hadanny A, Bechor Y, Catalogna M, et al (2018). Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse-randomized controlled trial. Front Psychol, 9, 2495.
DOI: 10.3389/fpsyg.2018.02495Efrati S, Hadanny A, Daphna-Tekoah S, et al (2018). Recovery of repressed memories in fibromyalgia patients managed with hyperbaric oxygen – case series presentation and suggested bio-psycho-social mechanism. Front Psychol, 9, 848.
DOI: 10.3389/fpsyg.2018.00848Çimşit M, Uzun G, & Yıldız S (2009). Hyperbaric oxygen therapy as an anti-infective agent. Expert Review of Anti-infective Therapy, 7(8), 1015-1026.
Ezra N, Dang K, Heuser G (2011). Improvement of attention span and reaction time with hyperbaric oxygen in patients with toxic injury due to mold exposure. Eur J Clin Microbiol Infect Dis, 30(1), 1-6.
DOI: 10.1007/s10096-010-0937-8
Mader JT, Brown GL, Guckian JC, et al (1980). A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits. J Infect Dis, 142(6), 915-22.
Delasotta LA, Hanflik A, Bicking G, et al (2013). Hyperbaric oxygen for osteomyelitis in a compromised host. Open Orthop J, 7, 114-117.
DOI: 10.2174/1874325001307010114
Ciofu O, Tolker-Nielsen T (2019). Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-how P. aeruginosa can escape antibiotics. Front Microbiol, 10, 913.
Kolpen M, Lerche CJ, Kragh KN, et al (2017). Hyperbaric oxygen sensitizes anoxic pseudomonas aeruginosa biofilm to ciprofloxacin. Antimicrob Agents Chemother, 61(11), e01024-17.
Gade PAV, Olsen TB, Jensen PØ, et al (2018). Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen in Pseudomonas aeruginosa PAO1 biofilms. PLoS ONE, e0198909.
DOI: 10.1371/journal.pone.0198909
Memar MY, Yekani M, Alizadeh N, et al (2019). Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections. Biomedicine & Pharmacotherapy, 109, 440-447.
DOI: 10.1016/j.biopha.2018.10.142
Kaye D (1967). Effect of hyperbaric oxygen on Clostridia in vitro and in vivo. Proc Soc Exp Biol Med, 124, 360.
İyikesici M, Slocum A, Slocum A, et al (2017). Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer. Cureus, 9(7), e1445.
DOI: 10.7759/cureus.1445Poff AM, Ari C, Seyfried TN, et al (2013). The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS ONE, 8(6), e65522.
DOI: 10.1371/journal.pone.0065522Moen I, Stuhr LE (2012). Hyperbaric oxygen therapy and cancer–a review. Target Oncol, 7(4), 233-242.
DOI: 10.1007/s11523-012-0233-xStępień K, Ostrowski RP, Matyja E (2016). Hyperbaric oxygen as an adjunctive therapy in managed of malignancies, including brain tumours. Med Oncol, 33(9), 101.
DOI: 10.1007/s12032-016-0814-0Lu QZ, Li X, Ouyang J, et al (2019). Further application of hyperbaric oxygen in prostate cancer. Med Gas Res, 8(4), 167-171.
DOI: 10.4103/2045-9912.248268Choudhury R (2018). Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med, 11, 431-442.
DOI: 10.2147/IJGM.S172460Health Quality Ontario (2017). Hyperbaric oxygen therapy for the management of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser, 17(5), 1-142.
Bhutani S, Vishwanath G (2012). Hyperbaric oxygen and wound healing. Indian J Plast Surg, 45(2), 316-324.
Perren S, Gatt A, Papanas N, et al (2018). Hyperbaric oxygen therapy in ischaemic foot ulcers in type 2 diabetes: a clinical trial. Open Cardiovasc Med J, 12, 80-85.
DOI: 10.2174/1874192401812010080
Eskes AM, Ubbink DT, Lubbers MJ, et al (2011). Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review. World J Surg, 35(3), 535-542.
DOI: 10.1007/s00268-010-0923-4
Hou S, Wu G, Liang J, et al (2019). Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels. Oncol Lett, 17(3), 3277-3282.
Boussi-Gross R, Golan H, Fishlev G, et al (2013). Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury – randomized prospective trial. PLoS One, 8(11), e79995.
DOI: 10.1371/journal.pone.0079995
Tal S, Hadanny A, Sasson E, et al (2017). Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci, 11, 508.
Meng XE, Zhang Y, Li N, et al (2016). Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of tlr4/nf-κB signaling pathway. Med Sci Monit, 22, 284-288.
Vlodavsky E, Palzur E, Feinsod M, et al (2005). Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, managed by hyperbaric oxygen therapy: a quantitative immunohistochemical study. Acta Neuropathol, 110(2), 120-126.
DOI: 10.1007/s00401-004-0946-8
Hadanny A, Abbott S, Suzin G, et al (2018). Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open, 8(9), e023387.
Rosario ER, Kaplan SE, Khonsari S, et al (2018). The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke. Neurol Res Int, 2018, 3172679.
Ostrowski RP, Stępień K, Pucko E, Matyja E (2017). The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications. Arch Med Sci, 13(5), 1217-1223.
Efrati S, Fishlev G, Bechor Y, et al (2013). Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial. PLoS One, 8(1), e53716.
DOI: 10.1371/journal.pone.0053716
Hadanny A, Efrati S (2015). Oxygen–a limiting factor for brain recovery. Crit Care, 19(1), 307.
DOI: 10.1186/s13054-015-1034-2
Hadanny A, Golan H, Fishlev G, et al. Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restor Neurol Neurosci, 33(4), 471-486.
Thom SR, Bhopale VM, Velazquez OC, et al (2006). Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology, 290(4), H1378-H1386.
DOI: 10.1152/ajpheart.00888.2005
Oyaizu T, Enomoto M, Yamamoto N, et al (2018). Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep, 8(1), 1288.
DOI: 10.1038/s41598-018-19670-x
Peña-Villalobos I, Casanova-Maldonado I, Lois P, et al (2018). Hyperbaric oxygen increases stem cell proliferation, angiogenesis and wound-healing ability of WJ-MSCs in diabetic mice. Front Physiol, 9, 995.
Fosen KM, Thom SR (2014). Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal, 21(11), 1634-1647.
MacLaughlin KJ, Barton GP, Braun RK, Eldridge MW (2019). Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression. Med Gas Res, 9(3), 139-144.
Meng XE, Zhang Y, Li N, et al (2016). Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway. Med Sci Monit, 22, 284-288.
Dulai PS, Gleeson MW, Taylor D, et al (2014). Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease. Aliment Pharmacol Ther, 39, 1266-1275.
Li F, Fang L, Huang S, et al (2011). Hyperbaric oxygenation therapy alleviates chronic constrictive injury-induced neuropathic pain and reduces tumor necrosis factor-alpha production. Anesth Analg, 113(3), 626-633.
DOI: 10.1213/ANE.0b013e31821f9544
Wu HH, Huang CC, Chang CP, et al (2018). Heat shock protein 70 (HSP70) reduces hepatic inflammatory and oxidative damage in a rat model of liver ischemia/reperfusion injury with hyperbaric oxygen preconditioning. Med Sci Monit, 24, 8096-8104.
Novak S, Drenjancevic I, Vukovic R, et al (2016). Anti-inflammatory effects of hyperbaric oxygenation during DSS-induced colitis in BALB/c mice include changes in gene expression of HIF-1α, proinflammatory cytokines, and antioxidative enzymes. Mediators Inflamm, 2016, 7141430.
Palzur E, Zaaroor M, Vlodavsky E, et al (2008). Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res, 1221, 126-133.
DOI: 10.1016/j.brainres.2008.04.078
Dave KR, Prado R, Busto R, et al (2003). Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice. Neuroscience, 120(1), 113-120.
DOI: 10.1016/S0306-4522(03)00244-6
Meyer JN, Leung MC, Rooney JP, et al (2013). Mitochondria as a target of environmental toxicants. Toxicol Sci, 134(1), 1-17.
Schmidt TM, Kao JY (2014). A little O2 may go a long way in structuring the GI microbiome. Gastroenterology, 147(5), 956-959.
DOI: 10.1053/j.gastro.2014.09.025
Nyabanga CT, Kulkarni G, Shen B (2017). Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis. Gastroenterology Report, 5(4), 320-321.
Albenberg L, Esipova TV, Judge CP, et al (2014). Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology, 147(5), 1055-1063.
DOI: 10.1053/j.gastro.2014.07.020
Crabbé A, Jensen PO, Bjarnsholt T, et al (2019). Antimicrobial tolerance and metabolic adaptations in microbial biofilms. Trends in Microbiology, 27(10), 850-863.
Hui J, Zhang ZJ, Zhang X, et al (2013). Repetitive hyperbaric oxygen treatment attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord. J Pain, 14(7), 747-758.
DOI: 10.1016/j.jpain.2013.02.003
Efrati S, Golan H, Bechor Y, et al (2015). Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial. PLoS ONE, 10(5), e0127012.
Vadas D, Kalichman L, Hadanny A, et al (2017). Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci, 11, 25.
Ying X, Tu W, Li S, et al (2019). Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats. Life Sciences, 229, 187-199.
DOI: 10.1016/j.lfs.2019.05.029
Efrati S, Fishlev G, Bechor Y, et al (2013). Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients – Randomized, Prospective Trial. PLoS ONE, 8(1), e53716.